David Tuller<p><strong>Professor Chris Ponting on “Replicated Blood-Based Biomarkers” for ME in Big Data Pre-Print Study</strong></p><p>By David Tuller, DrPH</p><p>Along with several colleagues, <a href="https://www.ed.ac.uk/profile/chris-ponting" rel="nofollow noopener noreferrer" target="_blank">Professor Chris Ponting</a>, a geneticist at the University of Edinburgh and a leading ME/CFS researcher, recently posted <a href="https://www.medrxiv.org/content/10.1101/2024.08.26.24312606v2" rel="nofollow noopener noreferrer" target="_blank">a pre-print</a> called <em>“Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity.”</em> (A pre-print is a paper that has not yet been formally peer-reviewed.) For this analysis, the investigators examined data for more than 3,000 molecular and cellular traits in samples from the UK Biobank, including from 1,455 ME cases and 131,303 controls. They found 116 traits that were significant among both female and male ME patients. </p><p>Earlier today, I spoke about the study with Professor Ponting, who is also the lead investigator for <a href="https://www.decodeme.org.uk/" rel="nofollow noopener noreferrer" target="_blank">DecodeME</a>, a major genome-wide association study of ME/CFS.</p> <p><a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://trialbyerror.org/tag/biobank/" target="_blank">#biobank</a></p>